Alcoholism is a concern which afflicts over 14 million Americans, almost 8% from the population of the United States. The majority of alcohol rehabilitation programs in use today possess a low rate of success, because of this many people have ventured into medications as a way to limit or stop their drinking problem. Two types of medications are currently used in the management of alcoholics, Aversive Medications and Anticraving Medications. Using two separate drugs to lose weight naturally can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the those who go through it you should err to the side of caution and allow the FDA do its job and demand some research be done so your public knows the side effects and dangers of the medications before we take them. Keep in mind that drug companies have been in business to generate income and that they would say almost anything to keep people on their medications. Researchers found that participants taking this drug to get a year, dropped excess weight within a month and have kept the load off throughout the 56 weeks of the study. Contrave is often a combination of the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs which might be made up of several active ingredient, which might make them more efficient and safer. Combo-pilling is the newest fad or also the newest into the future under scrutiny and so it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular is the fact that at the time of right now there aren't any long term prescription diet pills that have been licensed by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug may also raise hypertension and heartbeat, and shouldn't be used in individuals with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure and heartbeat and must not be used in patients with uncontrolled high blood pressure levels, as well as by a person with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients to the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking. Suboxone contains two drugs; buprenorphine and naloxone. The naloxone is irrelevant if your addict uses the medication properly, but if the tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone can be used correctly, the naloxone is destroyed in the liver after that uptake from the intestines and has no therapeutic effect. Buprenorphine will be the active substance; it is absorbed underneath the tongue (and through the mouth) but destroyed by the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation once the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I in addition have treated addicts who have had gastric bypass, in which the first part of the intestine is bypassed along with the stomach contents empty in to a more distal section of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the process with normal anatomy where the drug is taken up from the duodenum and transferred directly to the liver through the portal vein, where it can be quickly and completely destroyed. After gastric bypass naloxone can be taken up by portions of the intestine which are not served by the portal system, causing blood amounts of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.